Although it retains some traditional features, the house also displays a number of modernist elements, including skylights and large windows, which provided O’Keeffe with expansive views of the surrounding landscape and abundant natural light. O'Keeffe was insistent on building a studio that didn’t adhere strictly to traditional form, stating "I didn't want a Spanish house; I didn't want an Indian house, or a Mexican house; I wanted my house!"
She would often take the objects she found in her long desert wanderings back to her studio. As she recalled, “I have picked flowers where I found them, have picked up seashells and rocks and pieces of wood where there were seashells and rocks and pieces of wood that I liked. When I found the beautiful white bones on the desert I picked them up and took them home too. I have used these things to say what is to me the wideness and wonder of the world as I live in it.”